GPAT Question Paper 2026

About this paper

Graduate Pharmacy Aptitude Test (GPAT) 2026 question paper with an answer key at the end. The paper contains 125 multiple-choice questions spanning Pharmaceutics (tablet thickness variation, distillation methods such as McCabe Thiele and flash distillation, gaseous sterilization, ophthalmic buffers, and ampoule sealing), Pharmaceutical Chemistry and Analysis (active metabolites, phenothiazine SAR, nephelometry, EDTA titration, and asymmetric centers), Pharmacology and Physiology (mechanism of acarbose, phenobarbitone ionization, clozapine adverse effects, action potential propagation, and neurotransmitter transmission), Pharmacognosy (leaf drug quantitative microscopy, WHO chromatographic profiling of herbals, and herbal-drug interactions), and Pharmaceutical Jurisprudence (Drugs and Cosmetics Act schedules and statutory forms).

Exam

GPAT

Subject

GPAT

Year

2026

Questions

125

Pages

7

Answers included

Yes

Topics covered

• Pharmaceutics, unit operations (distillation), and industrial manufacturing
• Pharmaceutical jurisprudence (Drugs and Cosmetics Act schedules, regulatory forms)
• Physical pharmacy, ionization kinetics, and buffer systems
• Pharmaceutical chemistry, prodrug activation, and structure-activity relationships (SAR)
• Pharmaceutical analysis, nephelometry, and complexometric titrations
• Pharmacology, receptor mechanisms, and adverse drug reactions
• Human anatomy, physiology, endocrine function, and neurophysiology
• Pharmacognosy, quantitative microscopy, and herbal evaluation
• Immunology, microbiology, and sterilization techniques

Questions from this paper

1. Identify the active metabolite of acyclovir which binds DNA polymerase. Also, mention the type of chemical reaction involved in its metabolism:
2. Which buffer system is most commonly used in ophthalmic preparations?
3. McCabe Thiele method is primarily used to determine:
4. Nephelometric analysis is based on:
5. The complication associated with the use of clozapine as an antipsychotic includes:
6. Equilibrium distillation is also known as: